HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3
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چکیده
منابع مشابه
HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3.
HDL is a major atheroprotective factor, but the mechanisms underlying this effect are still obscure. HDL binding to scavenger receptor-BI has been shown to activate eNOS, although the responsible HDL entities and signaling pathways have remained enigmatic. Here we show that HDL stimulates NO release in human endothelial cells and induces vasodilation in isolated aortae via intracellular Ca2+ mo...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2004
ISSN: 0021-9738
DOI: 10.1172/jci200418004